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1. Catalano D, Licciulli F, Turi A, Grillo G, D'Elia D MitoRes: a bio-sequences resource of nuclearly encoded mitochondrial genes and products in metazoa Meeting: BITS 2005 - Year: 2005 Full text in a new tab Topic: Unspecified Abstract: The incredible explosion of “knowledge production” in Biology in the past two decades has created a critical need for bioinformatic instruments able to manage data and facilitate their retrieval and analysis. Molecular sequences and biological data on nuclear mitochondrial genes and their products are publicly available from a wide variety of mitochondrial specialized databases. Some are species-specific, mainly human dedicated, others contain only few species and for most of them the only sequences data reported concern proteins. We have developed MitoRes database to collect and integrate information on nuclearly encoded proteins and genes targeting the mitochondrion for all metazoan species and to provide a flexible and efficient tool for the export of bio-sequences in support of researchers interested in functional characterization of gene, transcript and amino acid sequences related to biogenesis, metabolism and pathological dysfunctions of mitochondria. |
2. D'Elia D, Turi A, Catalano D, Licciulli F, Tripoli G, Porcelli D, Saccone C, Caggese C MitoDrome2: a database of OXPHOS nuclear genes in Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae Meeting: BITS 2005 - Year: 2005 Full text in a new tab Topic: Unspecified Abstract: Mitochondrial disorders are clinical phenotypes associated with abnormalities of oxidative phosphorylation (OXPHOS), the primary energy-producing process of all aerobic organisms. Disorders of OXPHOS are recognized as the most common inborn errors of metabolism affecting at least one in 5000 newborn children. Except for complex II, which is composed of proteins all encoded by nuclear genes, the other OXPHOS complexes are built up of both mitochondrial and nuclear DNA encoded proteins; so, assembling the OXPHOS complexes and fine tuning their activity require specialized regulatory mechanisms to optimize the cross-talk between the two genomes and ensure the coordinated expression of their relevant products. In this context, the characterization of nuclear genes encoding for mitochondrial proteins and of functional elements regulating their expression is of crucial importance to clarify real genetic causes of mitochondrial diseases, to assess the correct diagnosis and set up new and effective therapies. Despite the long evolutionary divergent time, many key pathways that control development and cellular physiology are conserved between Drosophila and humans, and about 70% of the genes associated with human diseases have direct counterpart in the Drosophila genome. To investigate on the functional constraints acting on the evolution and on the regulatory mechanism coordinating the expression of OXPHOS genes we have identified and characterized sequence and structure of these genes in three species of diptera, D. melanogaster, D. pseudoobscura and A. gambiae, and compared them with their human counterparts. Data obtained from this study have been annotated in the MitoDrome2 database. The availability of data produced by our study in MitoDrome2 is expected to be particularly useful for biologists and clinicians interested in studies of functional genomics related to mitochondrial biogenesis, metabolism and to their pathological dysfunctions. |
3. Licciulli F, Grillo G, Turi A, Delle Foglie G, Catalano D CROSSMiner: a deductive system to discover biological relations Meeting: BITS 2007 - Year: 2007 Full text in a new tab Topic: Novel methodologies, algorithms and tools Abstract: Missing |
4. Logisci C, Salvemini E, Turi A, Grillo G, Malerba D, D’Elia D Discovering Relational Association Rules for the Characterization of UTR cis-regulatory modules Meeting: BITS 2009 - Year: 2009 Full text in a new tab Topic: Transcriptomics Gene Expression and Microarray Analysis Abstract: Missing |
5. Sbisà E, Catalano D, Gisel A, Grillo G, Licciulli F, Turi A, Liuni S, Pesole G, De Grassi A, Caratozzolo MF, D'Erchia AM, Navarro B, Tullo A, Saccone C p53FamTaG : a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data Meeting: BITS 2006 - Year: 2006 Full text in a new tab Topic: Miscellanea Abstract: Missing |